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KMID : 0043320100330081159
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Archives of Pharmacal Research
2010 Volume.33 No. 8 p.1159 ~ p.1163
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Two new dihydrofuranoisoflavanones from the leaves of Lespedeza maximowiczi and their inhibitory effect on the formation of advanced glycation end products
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Park Hyun-Young
Kim Gi-Beom
Kwon Yong-Soo
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Abstract
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Two new dihydrofuranoisoflavanones, 2′,4′,5-trihydroxy-[5″-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2″,3″:7,8)]-(3S)-isoflavanone (1) and 2′, 4′, 5-trihydroxy-[5″-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2″,3″:7,8)]-(3R)-isoflavanone (2) as well as one already-known compound, (+)-catechin (3), were isolated from an n-BuOH soluble fraction from the leaves of Lespedeza maximowiczi. Spectroscopic data was used to elucidate the structures of compounds 1 and 2. All of the isolates were evaluated in vitro for their inhibitory activity on the formation of advanced glycation end products (AGEs). Among these, compounds 1, 2, and 3 exhibited inhibitory activity against AGEs formation with IC50 values of 20.6, 18.4, and 5.6 μM, respectively.
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KEYWORD
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Lespedeza maximowiczi, Leguminosae, Dihydrofuranoisoflavanones, Advanced glycation end product, Diabetic complication
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